Meds: Antipsychotics

Antipsychotics Pristiq Zoloft Atenolol BuSpar Celexa Cogentin Cymbalta Depakote Effexor Klonopin Lamictal Lunesta Paxil Propranolol Prozac Risperdal Seroquel Serzone Viibryd Wellbutrin Zyprexa


Many antipsychotic drugs are available. The new ones are called second-generation antipsychotics. Latuda, also called lurasidone, is one of these SGA drugs. It has a favorable side effect profile, with low weight gain.

Research:This article uses the prescribing information for Latuda, and the public medical database, to learn more.


Strong meds: tips

For medications, the prescribing information shows details about weight gain. For Latuda (lurasidone) we learn that patients gain only 1 pound in the short-term. The control, taking placebo, lost a little weight.

Pooled data from short-term, placebo-controlled studies are presented. The mean weight gain was 0.43 kg for Latuda-treated patients compared to -0.02 kg for placebo-treated patients.

Latuda: Full Prescribing InformationQuestion

Next, how does Latuda compare to other antipsychotic drugs, such as Zyprexa (olanzapine) and Seroquel (quetiapine)? Latuda caused 1 pound of weight gain. Zyprexa caused 9 pounds. And Seroquel caused about 5 pounds.

Changes in weight from baseline for olanzapine was 4.15 kg and for quetiapine extended-release was 2.09 kg. Latuda: Full Prescribing Information

Weight gain on antipsychotics, short-term:

Latuda......1 pound
Seroquel....5 pounds
Zyprexa.....9 pounds

Glucose, lipids


Some antipsychotics increase levels of glucose and lipids (triglycerides) in the blood. This is sometimes harmful. Even diabetes can develop in consequence. Latuda has less impact on these blood levels.

And:For this reason it is a good choice if you happen to have hormonal (endocrine) or heart (cardiovascular) problems.

Additionally, it does not appear to have any significant adverse impact on the metabolic profile, such as weight, glucose, or lipid metabolism.... The use of this medication may be of particular interest in patients presenting with endocrine or cardiovascular abnormalities.

Lurasidone: an atypical antipsychotic


Dollar signs

Everything has a price. The price of Latuda is fairly high. It costs nearly $500 for a one-month supply of Latuda. This is the average price. A higher dose would have a higher price.

The average price for a 30-day supply of lurasidone is $475.98. Lurasidone: an atypical antipsychotic



Latuda, introduced in 2010 in the United States, is a fairly new drug. It is also an expensive one. But its side effect profile is favorable. It causes less weight gain than Zyprexa and Seroquel.


So:When you start Latuda, you can expect to gain about 1 pound. With Zyprexa and Seroquel, you can expect 5 or 9 pounds.

And:This weight gain is in the short-term. Over the long term, the total gained may multiply.


With antipsychotics, the mental effects are most important. If a drug makes you feel better, it is usually worth taking. The exception is with drugs like Zyprexa that can destroy your physical health.

But:With a drug that is probably gentler for most patients, like Latuda, there are fewer reasons to terminate the drug.


Antipsychotic meds are powerful. They reduce the symptoms of many mental disorders—not just schizophrenia and bipolar disorder, but also depression. Latuda is powerful and causes less weight gain than other, similar drugs.

Latuda: Official Site