Diabetes prevalence: 8.3% of the United States population
Skin. What are the skin changes that occur with acromegaly or excess growth hormone? One study in Brazil determined all the skin changes in 15 people who have acromegaly. The study found skin abnormalities in all patients.
We also observed the occasional presence of melasma, psoriasis, hidradenitis suppurativa, sebaceous hyperplasia, Civatte poikiloderma, xanthelasma and vascular lesions like cherry angiomas and facial telangiectasia....Dermatologic disorders in acromegaly
Acne. Acromegaly also may cause an increase in acne. This study found less acne than expected among the patients. Acromegaly causes oily skin—and this is expected to result in some acne.Acne
Acne was evidenced in our cases in a percentage very similar to other studies, although in a prevalence below the expected due to the high frequency of oily skin among the patients. Dermatologic disorders in acromegaly
Cutis verticis gyrata. Some disorders of the skin were not found. These problems are also known to occur in people who have acromegaly. But they do not occur in all cases. They may occur in only a minority of cases of acromegaly.
However, we did not see blue nevi, cutis verticis gyrata, mucocutaneous mixomas or psammomatous melanotic schwannomas. Dermatologic disorders in acromegaly
Cutis verticis gyrata is a condition that affects the scalp. Thick ridges appear on the scalp, usually going from the front to the back, not across from side to side. Cutis verticis gyrata is considered a rare condition.
Also: Acromegaly is one condition of many that cause cutis verticis gyrata. Many cases of acromegaly do not have cutis verticis gyrata.Cutis Verticis Gyrata: Acromegaly
Computer diagnosis. A fascinating new development in acromegaly diagnosis is from computer science. A person's face often shows signs of acromegaly. A study has found that it can be detected 86% of the time by a computer.
But physicians can only detect acromegaly 26% of the time. Please note that this is an average score. The most adept physician actually detected acromegaly 90% of the time—slightly better than the algorithm.
The accuracy of the computer model was 86%; the average of the 10 physicians was 26%. The worst individual physician, 16%, the best, 90%.Early diagnosis of acromegaly: computers vs clinicians
Perhaps this study mostly shows that physicians are often bad at detecting acromegaly—not that the computer is particularly good. The best physician did better than the algorithm.
Ancient. Acromegaly is not a new condition. It is ancient. It has existed as long as modern humans have existed. One study in Greece did an examination of a skeleton from the seventh century—1400 years ago.
The skeleton of the unfortunate Greek had clear signs of acromegaly—and also the presence of a brain lesion—a macroadenoma. Remember that acromegaly is often caused by pituitary adenomas.
All anatomical signs of acromegaly were present on this skull. More importantly, enlargement of the sella turcica clearly indicated the development of a macroadenoma, at the origin of the disease.A case of acromegaly: Greece, 7th century AD
Pachydermoperiostosis. Many of the features of acromegaly are shared in pachydermoperiostosis. This condition is often hereditary, meaning it runs in families. It mostly affects men. This condition is sometimes mistaken for acromegaly.Pachydermoperiostosis
TMJ. Problems with the temporomandibular joint result in facial pain. In patients with acromegaly, some joint degeneration is common—it occurs in about half of patients. This is linked to hearing problems.Jaw Pain
In all, 43% of the patients with acromegaly had hearing loss, and 20% had had an episode of otitis in at least one ear.... Auditory imaging showed that 50% of the patients had temporomandibular joint degeneration (TMJD).Evaluation of hearing in acromegaly
Story. It was a turbulent time in my life. My body had begun to change in small but perceptible ways. And when I visited by primary care physician, Dr. Stone was alarmed. She told me that my heart rate was going too fast.
Also, I had skin symptoms that indicated a possible endocrine problem. I had an urgent appointment with an endocrinologist on the other side of that coastal city. I remember that time, waiting and wonder what might be wrong.
So: At this point the endocrinologist had me do a urine test—for a possible excess of adrenal hormones.
All of my results were normal—and then I had a blood test for IGF-1: insulin-like growth factor. This too was normal. My testosterone was low. It is still uncertain, but the normal level of IGF-1 makes acromegaly much less likely.
Summary. Acromegaly has many signs—it affects every part of the body in some way. Growth hormone abuse carries the same symptoms. Acromegaly affects the size of the fingers and feet. It affects the strength and bulk of the muscles.
And: It affects the rate of diabetes diagnosis. It changes the skin of the body in unusual ways.